Neural-network solutions to stochastic reaction networks

نویسندگان

چکیده

The stochastic reaction network in which chemical species evolve through a set of reactions is widely used to model processes physics, chemistry and biology. To characterize the evolving joint probability distribution state space counts requires solving system ordinary differential equations, master equation, where size counting increases exponentially with type species. This makes it challenging investigate network. Here we propose machine learning approach using variational autoregressive solve equation. Training employs policy gradient algorithm reinforcement framework, does not require any data simulated previously by another method. In contrast simulating single trajectories, this tracks time evolution distribution, supports direct sampling configurations computing their normalized probabilities. We apply representative examples physics biology, demonstrate that accurately generates over time. exhibits plasticity representing multimodal cooperates conservation law, enables time-dependent rates efficient for high-dimensional networks, allowing flexible upper count limit. results suggest general study networks based on modern learning. Stochastic involve becomes as number reactive grows, but new neural provides an way track networks.

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ژورنال

عنوان ژورنال: Nature Machine Intelligence

سال: 2023

ISSN: ['2522-5839']

DOI: https://doi.org/10.1038/s42256-023-00632-6